In 2022, Houston Methodist made 12 bold bets on building the smart hospital of the future, and after opening that revolutionary facility in early 2025, they're doubling down with an even more ambitious vision: transforming into the intelligent healthcare system of the future with 10 new strategic bets for the next three years. These aren't incremental improvements or pilot programs, they're comprehensive investments in AI, virtual care, remote monitoring, and the fundamental reimagining of how healthcare systems operate in the digital age. They are tackling the unglamorous, but critical, business infrastructure that actually makes hospitals run: supply chain optimization, HR automation, finance modernization, and service automation that could dramatically improve patient experience by eliminating the friction points. The 10 new bets represent a roadmap for how health systems can evolve from being technology adopters to innovation leaders. Houston Methodist is defining what healthcare looks like when technology truly serves both patients and providers, creating systems that are not just smarter but fundamentally more human-centered.