Oncology care delivery is at a critical inflection point. Rising acuity, workforce shortages, care fragmentation, and increasing patient complexity demand new models of leadership and innovation. This session presents a replicable, zero‑cost, nurse‑driven redesign that reduced hospital‑acquired pressure injuries by 87.5% in one fiscal year at an NCI‑designated cancer center. Grounded in high‑reliability principles, evidence‑based practice, and workforce engagement, this session offers oncology leaders a practical blueprint for transforming safety, strengthening clinical judgment, and elevating system performance, without adding staff or financial burden.